Estradiol Valerate Injection is widely used for hormone replacement therapy (HRT) in menopausal women and as part of gender-affirming care for transgender women. Many users report positive experiences, including improved mood, emotional balance, and relief from symptoms like hot flashes and night sweats. For transgender women, it supports key physical changes such as breast development, fat redistribution, and softer skin.The injectable form offers consistent estrogen levels with less frequent dosing, usually every 1 to 2 weeks, making it both effective and convenient.