Apply Estogel once daily on clean, dry skin, usually on the outer arms, shoulders, or thighs as directed. Spread a thin layer gently over the area and let it dry completely before getting dressed. Do not apply it on the breasts, face, or broken skin. Avoid washing the area for at least an hour after application, and wash your hands after use. Use it regularly at the same time each day for best results, following your doctor’s advice.