Introduction Pain in the musculoskeletal system is a health problem that causes pain in the muscles, bones, joints, ligaments, and tendons. There are many individuals who suffer from pain that happens suddenly, disappears after rest, and comes back again. The following question arises - Can musculoskeletal pain come and go? Yes, musculoskeletal pain usually comes and goes depending on the reason, the nature of daily activity, physical strain, injuries, posture, and lifestyle habits. Knowing the reason for the intermittent pain will help to control the symptoms better.